Innovation in the Treatment of Brain Aneurysms with Bacterial Nanocellulose

Innovation in the Treatment of Brain Aneurysms with Bacterial Nanocellulose

Innovation in the Treatment of Brain Aneurysms with Bacterial Nanocellulose

Brain aneurysms are a serious medical condition that, in many cases, require invasive surgical intervention. This type of treatment, while effective, can be dangerous for patients at high risk. However, a new option based on Bacterial Nanocellulose (NCB) is marking a significant advance in medicine. Instead of resorting to invasive treatments, researchers are exploring how to use scaffold stents based  on Bacterial Nanocellulose (NCB) to treat brain aneurysms in a safer and more effective way.

What is Bacterial Nanocellulose (NCB) and how does it work?

 Bacterial Nanocellulose (NCB) is a natural, biodegradable and very resistant material that comes from bacterial fermentation. It is known for its unique properties, such as its high water absorption capacity, its biocompatibility and its nanometric structure that gives it a large surface area. In the treatment of brain aneurysms, Bacterial Nanocellulose (NCB) plays a fundamental role when used to create scaffold stents with biomimetic and magnetic characteristics, which allows a local and focused attraction of cells.

How is this achieved? A nanostructured bioactive coating was designed that makes a part of the stent magnetic and capable of attracting cells. To achieve this magnetization, the reaction of iron oxides III and II is used, which generates superparamagnetic iron oxide nanoparticles (SPION). Subsequently, the  magnetized Bacterial Nanocellulose (NCB) is coated with polyethylene glycol to improve its compatibility with the human body and avoid adverse reactions.

Bacterial Nanocellulose from NANOCELLFARMS COLOMBIA

Trials and Results

In the studies carried out so far, the biocompatibility and cytotoxicity of Bacterial Magnetic Nanocellulose (MNCB) have been evaluated. Smooth cells from the pig aorta were used for these trials and the results have been promising. Preliminary cell migration tests have shown that Bacterial Magnetic Nanocellulose (MNCB) has the potential to promote cell proliferation, a crucial process for the regeneration of damaged tissues in the aneurysm area.

In addition, it has been possible to successfully synthesize Bacterial Magnetic Nanocellulose (MNCB) impregnated with magnetic nanoparticles, creating a viable and resilient hydrogel membrane for neuroendovascular applications, such as stents. The results of these trials have shown that this material has low cytotoxicity, which means that it is safe for use in the human body.

Innovation in the Treatment of Brain Aneurysms with Bacterial Nanocellulose

Why is this innovation important?

The creation of a stent based on Bacterial Magnetic Nanocellulose (MNCB) offers a less invasive and less traumatic alternative compared to traditional methods. As a treatment that is best suited to the patient's needs, it has the potential to significantly reduce the risks associated with conventional surgical procedures.

The most remarkable thing about this innovation is the ability of Bacterial Nanocellulose (NCB) to attract and promote cell proliferation. Not only does this process improve the regeneration of blood vessels in the affected area, but it could also have wider applications in other medical treatments. Thus, the use of Magnetic Bacterial Nanocellulose (MNCB) in stents for brain aneurysms could open new doors in the treatment of various neurovascular conditions.

Innovation in the Treatment of Brain Aneurysms with Bacterial Nanocellulose

The future of neurovascular treatments?

If studies continue to demonstrate the efficacy and safety of Bacterial Magnetic Nanocellulose (MNCB), this approach could revolutionize the treatment of brain aneurysms, offering patients a less invasive, more effective, and less risky option. In the future, we could see an expansion of its use in other areas of medicine, where the unique properties of Bacterial Nanocellulose (NCB) NCB would be harnessed to create innovative solutions.

In short, Magnetic Bacterial Nanocellulose (MNCB) is not only changing the way we treat brain aneurysms, but also has the potential to transform medicine as we know it, with a safer, less invasive and profoundly innovative proposition.

 REFERENCES:

This information is issued from the Article. Bacterial Nanocellulose Magnetically Functionalized for Neuro-Endovascular treatment Authors : . Mónica Echeverry-Rendon, Lisa M. Reece, Fernando Pastrana, Sandra L. Arias, Akshath R. Shetty, Juan Jose Pavón, Jean Paul